SS-31

SS-31 (Elamipretide / Mitochondria-Targeting Peptide)

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Chemical Information:

• Molecular Formula: C₄₉H₈₇N₁₃O₁₀

• Molecular Weight: 936.3 g/mol

• Sequence: D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2′,6′-dimethyltyrosine)

• Molecular Structure: Refer to Certificate of Analysis for detailed structural information.

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Description:
SS-31, also known as Elamipretide, is a synthetic tetrapeptide designed to selectively target the inner mitochondrial membrane. Extensively researched for its ability to improve mitochondrial function and reduce oxidative stress, SS-31 plays a promising role in studies involving cellular energy production, mitochondrial dynamics, and degenerative disease models. Supplied in lyophilized powder form, SS-31 is formulated for research focused on bioenergetics, oxidative damage, and mitochondrial protection.

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Research Applications:
SS-31 is actively studied for its potential to:

• Enhance Mitochondrial Function: Investigate improvements in mitochondrial ATP production and membrane potential stabilization.

• Reduce Oxidative Stress: Explore its antioxidant-like effects by neutralizing reactive oxygen species (ROS) at the mitochondrial level.

• Support Cellular Energy Metabolism: Study its influence on metabolic efficiency and recovery in models of mitochondrial dysfunction.

• Protect Against Degenerative Conditions: Evaluate its role in research involving cardiovascular, muscular, and neurodegenerative disease models.

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Storage and Handling:

• Store lyophilized powder at -20°C.

• After reconstitution, store at 2-8°C and use promptly.

• Handle under aseptic conditions to preserve sterility and product stability.

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Product Specifications:

• Purity: ≥99% (HPLC Verified)

• Appearance: Lyophilized white to off-white powder

• Solubility: Soluble in sterile water or bacteriostatic water

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Important Note:
SS-31 is strictly FOR RESEARCH USE ONLY and is intended exclusively for in vitro research and laboratory experimentation by qualified professionals. It is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. This compound is not intended to diagnose, treat, cure, or prevent any disease. Introduction into humans or animals is strictly prohibited by law. Any misuse, misbranding, or mislabeling is a violation of federal regulations and may result in legal consequences under applicable federal, state, or local laws.

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References:
Referenced scientific publications include:

• Szeto, H. H., et al. (2008). “Mitochondria-Targeted Peptides: A Novel Class of Therapeutics.” Aging Cell.

• Zhao, K., et al. (2005). “Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane.” Journal of Biological Chemistry.

• Daubert, M. A., et al. (2017). “Elamipretide Improves Mitochondrial Function in Failing Human Hearts.” JACC: Basic to Translational Science.